The Development of a New Complexation Technique of Hydrocortisone Acetate with 2-Hydroxypropyl-β-Cyclodextrin: Preparation and Characterization
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چکیده
The Hydrocortisone acetate (Figure 1) is a white crystalline powder; it melts at about 220°C with decomposition and is practically insoluble in water 1mg/100mL [2]. One method to overcome the poorly water solubility of HA is the use of cyclodextrins (CDs), which have been extensively studied [3]. CDs have been extensively used as complexing agents to improve the solubility of a variety of poorly soluble drugs [4]. CDS are regarded by pharmaceutical scientists as a new group of pharmaceutical excipients [5].
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